Here is pretty cool and ambitious YouTube takeover. Its one of the first ones I have seen that also integrates the Facebook Connect functionality as part of the experience.
The YouTube campaign has been created by Dufresne Corrigan Scarlett and MediaMonks for beer brand Desperados. The takeover lets you interact with the story as it unfolds and also lets you bring your FB friends into the party by pulling in photos on the fly.
To experience it yourself visit: www.youtube.com/desperados